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We encourage our researchers to publish their findings in quality scientific journals. Following is an example of a recent publication:
Journal of Physiology, September 2005 -- P2X2 Knockout Mice and P2X2/P2X3 Double Knockout Mice Reveal a Role for the P2X2 Receptor Subunit in Mediating Multiple Sensory Effects of ATP by Debra Cockayne1, Philip Dunn2, Yu Zhong1, Weifang Rong3, Sara Hamilton4, Gillian Knight2, Huai-Zhen Ruan2, Bei Ma2, Ping Yip4, Philip Nunn1, Stephen McMahon4, Geoffrey Burnstock2 and Anthony Ford1
The paper reports that P2X2 and P2X3 receptors account for virtually all ATP responses in nerve cells that transmit sensory information (e.g., pain, a feeling of fullness, etc.) from the urinary bladder to the brain. In addition, the authors use P2X2 knockout and P2X2/P2X3 double knockout mice models to demonstrate that eliminating various combinations of P2X receptors results in abnormal urinary bladder reflexes as well as pain sensations, making P2X2 and P2X3 receptor subunits enticing targets for the treatment of urinary and pain disorders. Journal of Physiology website
1: Roche Palo Alto, 2: Royal Free and University College Medical School London, 3: University of Sheffield, 4: Kings College London
Trends in Genetics, September 2005 -- Computational Genetics: From Mouse to Human? by Janmei Wang, Guochun Liao, Jonathan Usuka and Gary Peltz, Roche Palo Alto
In this article, Roche Palo Alto scientists in the Genetics & Genomics Group describe a novel computational-analysis approach that enables researchers to identify a causative genetic factor by correlating a pattern of observable physiological or pathological differences among selected inbred mouse strains with a pattern of genetic variation. Compared with conventional methods which require many years to produce results, this new approach can be rapidly performed. The potential application of this genetic-analysis method to other experimental organisms, and possibly humans, is evaluated. Science Direct website
British Journal of Pharmacology, August 2005 -- Antagonism of ATP Responses at P2X Receptor Subtypes by the pH Indicator Dye, Phenol Red by Brian F. King1, Min Liu1, Andrea Townsend-Nicholson1, Jurg Pfister4, Fernanco Padilla4, Anthony P. Ford4, Joel R Gever4, Ian B Oglesby4, Stephanie Schorge1 and Geoffrey Burnstock,1
The authors report that common pH-sensitive dyes, such as Phenol red and related compounds, block P2X receptor activity in rodents. The results underscore the importance of eliminating these dyes from culture media and show that compounds of similar structure have promise as antagonists of P2X receptors in living systems, with potential implications for genitourinary diseases. British Journal of Pharmacology website
1:University College London, 4:Roche Palo Alto
 Science, October 2004 -- In Silico Genetics: Identification of a Novel Functional Element Regulating H2-Eα Gene Expression by by Guochun Liao1, Jianmei Wang1, Jingshu Guo1, John Allard1, Janet Cheng1, Anh Nguyen1, Steve Shafer2, Anne Puech3, John D. McPherson4, Dorothee Foernzler5, Gary Peltz1, Jonathan Usuka1
Roche Palo Alto scientists report a novel computational method to detect disease-causing genes accurately and rapidly. The approach correlates a pattern of observable physiological or pathological differences among selected inbred strains of mice with a pattern of genomic variation and has the potential to uncover currently unknown genetic factors contributing to a host of different human diseases. Science website
1:Roche Palo Alto, 2:Stanford University Medical Center, 3:Centre National de Genotypage, 4:Washington University School of Medicine, 5:Roche Center for Medical Genomics
Nature Reviews Drug Discovery, September 2004 -- Biochemical Mechanisms of Drug Action: What Does It Take for Success? by David C. Swinney
This paper puts forth two simple rules to help researchers understand the connection between biochemical mechanism and therapeutic success. These rules offer an opportunity to minimize the inherent risks in drug discovery and better predict the success of drug candidates, particularly drug antagonists and inhibitors. Nature website
Science, January 2004 -- Regulation of Bone Mass in Mice by the Lipoxygenase Gene Alox 15, by researchers at Oregon Health & Science University, Portland Veterans Affairs Medical Center and Roche.
This publication reports on work identifying an enzyme affecting skeletal development in mice that may have relevance to human osteoporosis. Collaborating scientists from Roche are Gary Peltz, co-author; John D.Allard, Zafrira Avnur, Tania Nikolcheva, David Rotstein and Ruth V. Waters.
Following is a searchable database with references to journal publications authored by Roche Palo Alto researchers since 1995. The database, which is updated quarterly, includes publication title, authors, source and business unit.
Enter Publications Database
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